What Makes CombiPatch® Different?

Effective Symptom Relief with Smaller Daily Doses Compared to Pills*

A small transparent patch, CombiPatch uses the patented DOT Matrix delivery system. Upon application to your skin, the patch continuously releases both estradiol (a form of estrogen) and norethindrone acetate (a progestin) directly into your bloodstream. That's why CombiPatch can help to treat certain moderate to severe symptoms associated with menopause with smaller daily doses compared to pills that need to be first digested, and then processed through the liver.*

*This does not mean that CombiPatch is safer or more effective than hormone therapy (HT) pills or other hormone therapies.

Learn more about how CombiPatch works.

Designed to Provide a Choice of Dosing and Regimen Options

CombiPatch can be used in one of two ways—based on what you and your doctor decide:

  • Continuous Combined regimen means you will use only CombiPatch continuously throughout the month. Women prescribed a Continuous Combined regimen with CombiPatch receive a consistent level of progestin and may experience spotting, particularly in the first six months, but it generally decreases with time.
  • Continuous Sequential regimen means you will be alternating treatment with CombiPatch and Minivelle® (estradiol transdermal system) over the month. Women prescribed a Continuous Sequential regimen with CombiPatch and Minivelle receive progestin during only half of the month and usually experience a regular monthly bleed.

There are many important things to consider when choosing a CombiPatch dosing regimen. Talk to your healthcare provider about your preference for a predictable monthly bleed vs the potential for occasional spotting, your history of menstruation, and how far along you are in your menopause journey. Depending on your personal preferences, history, and time since you started menopause, your doctor can recommend an appropriate dosing regimen.

CombiPatch is available in two dosage options (reflected in two patch sizes). This allows your doctor to make adjustments to your treatment (specifically your progestin level) according to your symptoms and any side effects you may be experiencing. For example, many women experience irregular bleeding (spotting) during the first year on a Continuous Combined regimen with the kind of hormones contained in CombiPatch (estrogen and progestin). Spotting usually decreases during the first year of using CombiPatch, but your doctor can also make adjustments to your treatment plan or dose based on your personal experience. Make sure you schedule follow-up visits with your doctor every 3 to 6 months to discuss your progress, your concerns, and also about whether you still need treatment with CombiPatch. Never start or stop any treatment without talking to your doctor first.

Read more about dosing regimens and what to expect while using CombiPatch.

Dosing Options

CombiPatch offers the convenience of two dosage options in a small and discreet combination HT patch.

For important safety information about Minivelle, click here.

Petite and Discreet

Small and transparent—CombiPatch is a small transparent patch, which uses the patented DOT Matrix technology delivery system to allow hormones to be absorbed directly into your bloodstream through your skin.

Simple-to-Use Option

CombiPatch has been shown to have a low level of skin irritation and excellent skin adhesion. The patch is designed to stay on as you go about your busy life. It sticks with you while showering and bathing, and even in the pool, so you can go about your active life while wearing the patch.

Twice Weekly

CombiPatch is changed twice a week according to a schedule that you set based on when you begin.

Hormones in CombiPatch

CombiPatch is a transdermal hormone therapy (HT) patch that contains both estrogen (estradiol) and progestin (norethindrone acetate). The progestin in CombiPatch may help to reduce the risk of certain types of uterine cancers and is specifically designed for postmenopausal women who still have their uterus.

Find out how CombiPatch works.

Dosing Options

CombiPatch offers the convenience of two dosage options in a small and discreet combination HT patch.

Multiple dosing options to meet your needs

Patches are not shown at actual size.

CombiPatch ISI CombiPatch ISI CombiPatch ISI Full Prescribing Information for CombiPatch www.fda.gov/medwatch Full Prescribing Information for CombiPatch www.fda.gov/medwatch Full Prescribing Information for CombiPatch www.fda.gov/medwatch
Minivelle ISI Vivelle-Dot ISI Vivelle-Dot ISI Area10 Area11 Full Prescribing Information for Vivelle-Dot www.fda.gov/medwatch
Indication and Important Safety Information for CombiPatch Indication and Important Safety Information for Vivelle-Dot
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