Continuous Sequential Regimen

Continuous Sequential Regimen

CombiPatch® offers two dosing options to treat certain moderate to severe symptoms of menopause. To decide which treatment plan may work for you, talk to your doctor about the following:

  • Your preference for a predictable monthly bleed vs the risk of occasional spotting
  • Your personal history of menstruation
  • How far along you are in your menopause journey

Depending on your personal preferences, history, and time since you started menopause (among other considerations), your doctor can recommend a dosing regimen that might be right for you.

If you and your doctor have selected a Continuous Sequential regimen:

  • Apply Minivelle® (estradiol transdermal system) for the first two weeks of your monthly schedule and CombiPatch for the second two weeks
  • Remove one patch and apply a new one every 3 to 4 days, according to your schedule
  • A predictable monthly bleed will most likely occur

The calendar to the right shows an example of when you'll apply a new transdermal patch to your lower abdomen throughout the 4-week schedule.

The Continuous Sequential regimen with CombiPatch and Minivelle provides a consistent level of estrogen throughout the 4-week schedule, but progestin during only half of the schedule. This plan is similar to a natural menstrual cycle and women prescribed the Continuous Sequential regimen often experience regular monthly bleeding.

Keep your doctor regularly informed about your bleeding patterns and other issues related to your hormone therapy. It's important to schedule follow-up visits with your doctor every 3 to 6 months to discuss your symptoms, health risks, and treatment goals. All of these are important and all can change over time. Communicate openly with your physician about your treatment with CombiPatch, how it's affecting your daily routine, and when it might be time to consider switching to a Continuous Combined regimen. CombiPatch offers options to help you and your doctor address your needs now and in the future. It's important that you take your medication as prescribed. Never start or stop any treatment plan without talking to your doctor first.

Please Click Here for the Full Product Information, including Boxed WARNING, for CombiPatch.

Please Click Here for the Full Product Information, including Boxed WARNING, for Minivelle.

Continuous Cyclic Hormone Therapy with CombiPatch and Vivelle-Dot

This calendar is just an example. You will be able to choose the days of the week you change patches.

CombiPatch ISI CombiPatch ISI CombiPatch ISI Full Prescribing Information for CombiPatch www.fda.gov/medwatch Full Prescribing Information for CombiPatch www.fda.gov/medwatch Full Prescribing Information for CombiPatch www.fda.gov/medwatch
Minivelle ISI Vivelle-Dot ISI Vivelle-Dot ISI
Indication and Important Safety Information for CombiPatch Indication and Important Safety Information for Vivelle-Dot
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Noven is working diligently to improve product availability, but intermittent spot retail shortages of CombiPatch may continue for the remainder of 2016

The Pharmacy Locator Service (1-800-420-2719) may be able to identify a pharmacy that might have CombiPatch in stock. If you are unable to find a pharmacy that has Combi Patch in stock, please contact your healthcare provider.

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