CombiPatch DOT Matrix™ Hormone Therapy (HT)
Hormone Delivery
CombiPatch was the first transdermal patch marketed in the United States designed to deliver estrogen (estradiol) and progestin (norethindrone acetate). This innovative science and patented DOT Matrix™ technology allows patients who prefer a patch, a convenient and easy alternative to taking two oral products. Plus, it’s the smallest combination transdermal available. CombiPatch is for appropriate menopausal women with an intact uterus for treatment of moderate to severe menopausal symptoms1 such as hot flashes, night sweats and vaginal dryness.2

Learn more about how CombiPatch works.

CombiPatch Prescribing Information PDF
Estrogens and progestins should not be used for the prevention of cardiovascular disease or dementia.

The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo.

The Women’s Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus MPA relative to placebo. It is unknown whether this finding applies to younger postmenopausal women.

Other doses of oral conjugated estrogens with MPA, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

Estrogens and estrogens/progestins combined should not be used in women with undiagnosed abnormal genital bleeding; known, suspected, or history of breast cancer; known or suspected estrogen-dependent neoplasia; active deep vein thrombosis, pulmonary embolism, or history of these conditions; active or recent arterial thromboembolic disease; liver dysfunction or disease; or known or suspected pregnancy.

In clinical trials with CombiPatch, the most common side effects were breast pain, dysmenorrhea, and headache.

1CombiPatch is indicated for women with an intact uterus for the treatment of moderate to severe vasomotor symptoms associated with menopause, and moderate to severe symptoms of vulvar and vaginal atrophy associated with menopause. 2When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered.



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Available by prescription only.

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