How to Use It

It’s easy to use CombiPatch. Just follow these steps.

1.  Determine your schedule for twice-a-week application.

  • Decide which two days you'll change your patch. Your CombiPatch individual carton contains a calendar card printed in its inner flap. Mark the two-day schedule you plan to follow on your carton's inner flap.

  • Be consistent.

  • If you forget to change your patch on the correct date, apply a new one as soon as you remember.

  • No matter what day this happens, stick to the schedule you have marked on the inner flap of your carton (your calendar card).
2.  Before you apply the CombiPatch System, prepare your skin.
Make sure your skin is:
  • Clean (freshly washed), dry and cool.

  • Free of any powder, oil, moisturizer or lotion.

  • Free of cuts and or irritations (rashes or other skin problems).
3.  How to Apply the CombiPatch System.
  • Tear open the pouch at the tear notch (do not use scissors). Each patch is individually sealed in a protective pouch.

  • Remove the patch from the package and apply immediately. Apply patch to lower abdomen, below the waistline. Avoid the waistline, since clothing may cause the patch to rub off. DO NOT APPLY PATCH TO BREASTS.
  • Holding the patch with the rigid protective liner facing you, remove half of the liner, which covers the sticky surface of the patch. Avoid touching the sticky side of the patch with your fingers.
  • Using the other half of the rigid protective liner as a handle, apply the sticky side of the patch to the selected area of the abdomen.
  • Press the sticky side of the patch firmly into place and smooth it down.

  • While still holding the sticky side down, fold back the other half of the patch.
  • Grasp an edge of the remaining protective liner and gently pull it off. Avoid touching the sticky side of the patch with your fingers.


  • Press the entire patch firmly into place with the palm of your hand. Continue to apply pressure for approximately 10 seconds. Make sure the patch properly adheres to your skin.

  • Go over the edges with your finger to ensure good contact around the patch.



Note: If the patch should come off, put the same patch back on a different site. When changing your patch, based on your twice-a-week schedule, apply your new patch to a different site. Do not apply a new patch to that same area for at least one week.

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT COMBIPATCH (A COMBINATION OF ESTROGEN AND PROGESTIN HORMONES)?

Do not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia (decline in memory and thinking skills). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots, and may increase your risk of dementia.

Do not use CombiPatch if you have had your uterus removed (hysterectomy). CombiPatch should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.

The most common side effects that may occur with CombiPatch are breast pain, vaginal bleeding, and headache.

CombiPatch is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; and treat certain conditions in which a young woman’s ovaries do not produce enough estrogens naturally. If you use CombiPatch only to treat your dryness, itching and burning in or around the vagina, talk with your health care professional about whether a topical vaginal product would be better for you.

You and your health care professional should talk regularly about whether you still need treatment with CombiPatch and whether you are taking the lowest dose that works for you.

The information contained within this web site is appropriate for U.S. residents only. A visit to this site should not replace a visit to your doctor.

Available by prescription only.

Copyright © 2006 Novogyne Pharmaceuticals. All rights reserved.