About CombiPatch

CombiPatch is used for the treatment of moderate to severe menopausal symptoms1 such as hot flashes, night sweats and vaginal dryness. It was the first patch marketed in the United States with both estrogen and progestin all in one convenient patch.

Made with an innovative technology called DOT Matrix™, CombiPatch is the smallest HT patch on the market.

CombiPatch is made specifically for women who still have their uterus. If you’ve had your uterus removed, ask your doctor about Vivelle-Dot™ (estradiol transdermal system), an estrogen-only DOT Matrix™ patch also marketed by Novogyne Pharmaceuticals. For important safety information about Vivelle-Dot, click here.

Treatment Options

There are two treatment options for CombiPatch. The first one is called continuous combined hormone therapy. This requires taking only CombiPatch (no other hormone therapies) continuously throughout the month. You will probably not get a predictable monthly bleed for this type of treatment, and you may experience some irregular bleeding for the first six months.

The second treatment option is cyclic hormone therapy. This treatment requires an estrogen-only therapy like the Vivelle-Dot patch only for the first 14 days of your 28 day cycle, then switches to CombiPatch only for the last 14 days. You should experience a predictable monthly bleed with this treatment. Get more information on cyclic hormone therapy.

Most Common Side Effects

As with any medication, side effects can occur. The most common side effects that can occur with CombiPatch are breast pain, vaginal bleeding and headache.

Learn more about how CombiPatch works.

See Vivelle-Dot Prescribing Information PDF.


WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT COMBIPATCH (A COMBINATION OF ESTROGEN AND PROGESTIN HORMONES)?

Do not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia (decline in memory and thinking skills). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots, and may increase your risk of dementia.

Do not use CombiPatch if you have had your uterus removed (hysterectomy). CombiPatch should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.

The most common side effects that may occur with CombiPatch are breast pain, vaginal bleeding, and headache.

1CombiPatch is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; and treat certain conditions in which a young woman’s ovaries do not produce enough estrogens naturally. If you use CombiPatch only to treat your dryness, itching and burning in or around the vagina, talk with your health care professional about whether a topical vaginal product would be better for you.

You and your health care professional should talk regularly about whether you still need treatment with CombiPatch and whether you are taking the lowest dose that works for you.

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT VIVELLE-DOT (AN ESTROGEN HORMONE)?

Estrogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia (decline in memory and thinking skills).

Vivelle-Dot should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, pregnant.

The most common side effects that may occur with Vivelle-Dot are headache, breast tenderness, and back pain.

Vivelle-Dot is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; help reduce your chances of getting osteoporosis (thin weak bones); and treat certain conditions in which a young woman’s ovaries do not produce enough estrogens naturally. Vivelle-Dot 0.025 mg/day is only used to prevent osteoporosis from menopause. If you use Vivelle-Dot only to treat your dryness, itching, and burning in and around your vagina or if you use Vivelle-Dot only to prevent osteoporosis from menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you.

You and your healthcare professional should talk regularly about whether you still need treatment with Vivelle-Dot.

DOT Matrix™is a trademark of Noven Pharmaceuticals, Inc.

The information contained within this web site is appropriate for U.S. residents only. A visit to this site should not replace a visit to your doctor.

Available by prescription only.

Copyright © 2006 Novogyne Pharmaceuticals. All rights reserved.