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There are two treatment options for CombiPatch. The first, continuous
combined therapy, uses CombiPatch all month. But the second option,
cyclic therapy, uses both CombiPatch and an estrogen-only treatment.
Here’s a few commonly asked questions and answers about cyclic therapy.
This treatment is for women who have a uterus and are experiencing moderate to
severe menopausal symptoms1. The
treatment uses estrogen only, such as Vivelle-Dot, for the first two weeks and estrogen and
progestin combined, such as CombiPatch, for the last two weeks of your 4-week cycle. Progestin
is added to estrogen for women with a uterus, because if estrogen is given alone, it can
sometimes cause excessive growth of the uterus lining that can lead to cancer. This risk
is greatly decreased by adding progestin. Before menopause, progesterone was the hormone your
body produced that was responsible for the monthly shedding of the uterine lining, which you
experience as your period. Taken with estrogen after menopause, progestin acts similarly.
For important safety information about Vivelle-Dot, click here.
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Yes, this treatment often results in a regular, predictable bleeding, at the same
time of the month, each month. Discuss your bleeding pattern with your doctor to see
if follow-up care is needed.
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Vivelle-Dot™ provides estrogen only, and
CombiPatch provides estrogen and progestin. Both are small, ultra-thin patches that are worn on your
lower abdomen (stomach). Vivelle-Dot and CombiPatch release hormones through
the skin and directly into your bloodstream.
For women who are interested in the source of the hormones in their therapy, the estrogen in
Vivelle-Dot (estradiol) and the estrogen and progestin in CombiPatch (estradiol and norethindrone acetate)
are chemically synthesized from plant sources. This does not mean that Vivelle-Dot and CombiPatch are safer
or more effective than other hormone therapies.
CombiPatch and Vivelle-Dot use the patented DOT Matrix™ technology. “DOT”
stands for “Delivery Optimized Thermodynamics.” These patches are specifically
designed for convenience. Despite being so small, Vivelle-Dot and CombiPatch provide controlled,
sustained release of hormones over 3 ½ days.
The patches are applied to your lower abdomen just twice a week. In clinical
trials, the patches stayed on well and had a low occurrence of skin irritation.
The patches are designed to stay on during various activities including
swimming, showering and bathing. So you can enjoy an active lifestyle while
wearing them.
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Apply the patch twice-weekly to your lower abdomen below your waistline. Change the
location each time you put on a new patch. Get more information on
applying the
patch.
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See Vivelle-Dot Prescribing Information PDF.
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